In vitro antimicrobial activity of a new series of 1,4-naphthoquinones
dc.contributor.author | Riffel, Alessandro | pt_BR |
dc.contributor.author | Medina, Luis Fernando da Costa | pt_BR |
dc.contributor.author | Stefani, Valter | pt_BR |
dc.contributor.author | Santos, R.C. | pt_BR |
dc.contributor.author | Bizani, Delmar | pt_BR |
dc.contributor.author | Brandelli, Adriano | pt_BR |
dc.date.accessioned | 2010-04-27T04:16:46Z | pt_BR |
dc.date.issued | 2002 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/21273 | pt_BR |
dc.description.abstract | The antibacterial activity of a series of 1,4-naphthoquinones was demonstrated. Disk diffusion tests were carried out against several Gram-positive and Gram-negative bacteria. The compound 5-amino- 8-hydroxy-1,4-naphthoquinone was the most effective, presenting inhibition zones measuring 20 mm against staphylococci, streptococci and bacilli at 50 μg/ml. Methicillin-resistant Staphylococcus aureus and several clinical isolates of this bacterium were also inhibited. Naphthazarin, 5-acetamido-8-hydroxy-1,4-naphthoquinone, and 2,3- diamino-1,4-naphthoquinone were the next most active compounds. The minimal inhibitory concentration of the active compounds was determined against S. aureus, ranging from 30 to 125 μg/ml. All compounds presented a minimal bactericidal concentration higher than 500 μg/ml, indicating that their effect was bacteriostatic. The EC50, defined as the drug concentration that produces 50% of maximal effect, was 8 μg/ml for 5-amino-8-hydroxy-1,4-naphthoquinone against S. aureus, S. intermedius, and S. epidermidis. These results indicate an effective in vitro activity of 5-amino-8-hydroxy-1,4-naphthoquinone and encourage further studies for its application in antibiotic therapy. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research =Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto. Vol. 35, no. 7 (jul. 2002), p. 811-818 | pt_BR |
dc.rights | Open Access | en |
dc.subject | 5-Amino-8-hydroxy-1,4- naphthoquinone | en |
dc.subject | Naftoquinonas | pt_BR |
dc.subject | Antimicrobial agent | en |
dc.subject | Atividade antimicrobiana | pt_BR |
dc.subject | Staphylococcus aureus | en |
dc.subject | Quinone | en |
dc.subject | Naphthazarin | en |
dc.subject | 5-Acetamido-8-hydroxy-1,4-naphthoquinone | en |
dc.subject | 2,3-Diamino-1,4-naphthoquinone | en |
dc.title | In vitro antimicrobial activity of a new series of 1,4-naphthoquinones | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000327627 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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