Encefalopatia hepática secundária à intoxicação por Tephrosia cinerea em ovinos
dc.contributor.author | Silveira, Aline Monteiro | pt_BR |
dc.contributor.author | Campos, Edipo Moreira | pt_BR |
dc.contributor.author | Vaz, Antônio Fernando de Melo | pt_BR |
dc.contributor.author | Lorenzo, Cíntia de | pt_BR |
dc.contributor.author | Driemeier, David | pt_BR |
dc.contributor.author | Gouvêa, Fernando Henrique Furlan | pt_BR |
dc.contributor.author | Dantas, Antonio Flávio Medeiros | pt_BR |
dc.contributor.author | Riet-Correa, Franklin | pt_BR |
dc.date.accessioned | 2018-07-31T02:33:42Z | pt_BR |
dc.date.issued | 2018 | pt_BR |
dc.identifier.issn | 0100-736X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/180849 | pt_BR |
dc.description.abstract | In the semiarid region of northeastern Brazil, Tephrosia cinerea causes periacinar hepatic fibrosis in sheep with severe ascites and, occasionally, nervous signs. Sixteen sheep from six outbreaks of T. cinerea poisoning were studied. All sheep had histologic lesion of periacinar fibrosis and six showed, in the brain, vacuolization (spongy degeneration) of the white matter and junction between grey and white matter and presence of Alzheimer type II astrocytes in the grey matter. The disease was produced experimentally in two sheep, that presented porto-sistemic shunts and similar histologic lesions as those observed in the spontaneous cases. Immunohistochemistry revealed weak labelling with anti-GFAP antibodies suggesting a degenerative alteration of astrocytes with accumulation of dense bodies and reduction of the GFAP. There was strong labelling with anti-S100 antibodies suggesting cellular reactivity with proliferation of mitochondria and endoplasmatic reticulum. Such alterations are characteristic of the effects caused by ammonia on the astrocytes. It is concluded that in poisoning by T. cinerea nervous signs due to hepatic encephalopathy occur in some sheep. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Pesquisa veterinária brasileira. Vol. 38, no. 4 (Abr. 2018), p. 635-641 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Intoxicacao por plantas | pt_BR |
dc.subject | Poisonous plants | en |
dc.subject | Hepatic encephalopathy | en |
dc.subject | Tephrosia cinerea | pt_BR |
dc.subject | Doenças do sistema nervoso | pt_BR |
dc.subject | Plant poisoning | en |
dc.subject | Tephrosia cinerea | en |
dc.subject | Encefalopatia hepática | pt_BR |
dc.subject | Sheep | en |
dc.subject | Ovinos | pt_BR |
dc.subject | Hepatotoxic plants | en |
dc.subject | Imuno-histoquímica | pt_BR |
dc.subject | Neurological disorders | en |
dc.subject | Status spongiosus | en |
dc.subject | GFAP | en |
dc.subject | S100 | en |
dc.subject | Toxicoses | en |
dc.title | Encefalopatia hepática secundária à intoxicação por Tephrosia cinerea em ovinos | pt_BR |
dc.title.alternative | Hepatic encephalopathy secondary to poisoning by Tephrosia cinerea in sheep | en |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001073176 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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