Women with primary ovarian insufficiency have lower bone mineral density
dc.contributor.author | Amarante, Fernanda do | pt_BR |
dc.contributor.author | Vilodre, Luiz Cezar Fernandes | pt_BR |
dc.contributor.author | Maturana, Maria Augusta | pt_BR |
dc.contributor.author | Spritzer, Poli Mara | pt_BR |
dc.date.accessioned | 2013-11-20T01:46:10Z | pt_BR |
dc.date.issued | 2011 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/80734 | pt_BR |
dc.description.abstract | The aim of the present study was to assess the prevalence of osteoporosis in a sample of 32 patients with spontaneous primary ovarian insufficiency (POI) in comparison to reference groups of 25 pre- and 55 postmenopausal women. Hip (lumbar) and spinal bone mineral density (BMD) measurements were performed by dual-energy X-ray absorptiometry in the three groups. The median age of POI patients at the time of diagnosis was 35 years (interquartile range: 27-37 years). The mean ± SD age of postmenopausal reference women (52.16 ± 3.65 years) was higher than that of POI (46.28 ± 10.38 years) and premenopausal women (43.96 ± 7.08; P = 0.001) at the time of BMD measurement. Twenty-seven (84.4%) POI women were receiving hormone replacement therapy (HRT) at the time of the study. In the postmenopausal reference group, 30.4% were current users of HRT. Lumbar BMD was significantly lower in the POI group (1.050 ± 0.17 g/cm2) compared to the age-matched premenopausal reference group (1.136 ± 0.12 g/cm2; P = 0.040). Moreover, 22 (68.7%) POI women had low bone density (osteopenia/osteoporosis by World Health Organization criteria) versus 47.3% of the postmenopausal reference group (P = 0.042). In conclusion, the present data indicate that BMD is significantly lower in patients with POI than in age-matched premenopausal women. Also, the prevalence of osteopenia/osteoporosis is higher in POI women than in women after natural menopause. Early medical interventions are necessary to ensure that women with POI will maintain their bone mass. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 14, no. 1 (Jan. 2011), p. 78-83 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Premature ovarian failure | en |
dc.subject | Insuficiência ovariana primária | pt_BR |
dc.subject | Menopausa precoce | pt_BR |
dc.subject | Premature menopause | en |
dc.subject | Osteoporosis | en |
dc.subject | Osteoporose | pt_BR |
dc.subject | Densidade óssea | pt_BR |
dc.subject | Bone mineral density | en |
dc.subject | Hipogonadismo | pt_BR |
dc.subject | Hypogonadism | en |
dc.title | Women with primary ovarian insufficiency have lower bone mineral density | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000770686 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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