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dc.contributor.authorPiffer, Alicia Corbellinipt_BR
dc.contributor.authorSantos, Francine Melise dospt_BR
dc.contributor.authorThomé, Marcos Paulopt_BR
dc.contributor.authorRosa, Camila Diehl dapt_BR
dc.contributor.authorGarcia, Ane Wichine Acostapt_BR
dc.contributor.authorKinskovski, Uriel Perinpt_BR
dc.contributor.authorSchneider, Rafael de Oliveirapt_BR
dc.contributor.authorGerber, Alexandra Lehmkuhlpt_BR
dc.contributor.authorFeltes, Bruno Césarpt_BR
dc.contributor.authorSchrank, Augustopt_BR
dc.contributor.authorVasconcelos, Ana Tereza Ribeiro dept_BR
dc.contributor.authorLenz, Guidopt_BR
dc.contributor.authorSilva, Lívia Kmetzsch Rosa ept_BR
dc.contributor.authorVainstein, Marilene Henningpt_BR
dc.contributor.authorStaats, Charley Christianpt_BR
dc.date.accessioned2023-11-30T03:23:26Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/267824pt_BR
dc.description.abstractCryptococcus neoformans and Cryptococcus gattii are the etiological agents of cryptococcosis, a high mortality disease. The development of such disease depends on the interaction of fungal cells with macrophages, in which they can reside and replicate. In order to dissect the molecular mechanisms by which cryptococcal cells modulate the activity of macrophages, a genome-scale comparative analysis of transcriptional changes in macrophages exposed to Cryptococcus spp. was conducted. Altered expression of nearly 40 genes was detected in macrophages exposed to cryptococcal cells. The major processes were associated with the mTOR pathway, whose associated genes exhibited decreased expression in macrophages incubated with cryptococcal cells. Phosphorylation of p70S6K and GSK-3β was also decreased in macrophages incubated with fungal cells. In this way, Cryptococci presence could drive the modulation of mTOR pathway in macrophages possibly to increase the survival of the pathogen.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto. Vol. 44, no. 3 (2021), e20200390, 13 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCryptococcus neoformanspt_BR
dc.subjectMacrophageen
dc.subjectCryptococcus gattiipt_BR
dc.subjectCryptococcusen
dc.subjectRNAseqen
dc.subjectMacrófagospt_BR
dc.subjectRNApt_BR
dc.subjectmTOR pathwayen
dc.subjectInteratomic networksen
dc.titleTranscriptomic analysis reveals that mTOR pathway can be modulated in macrophage cells by the presence of cryptococcal cellspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001172711pt_BR
dc.type.originNacionalpt_BR


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