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dc.contributor.authorReis, Carlos Guilherme Rosapt_BR
dc.contributor.authorBastos, Leonardo Marensipt_BR
dc.contributor.authorChitolina, Rafaelpt_BR
dc.contributor.authorLopes, Matheus Gallaspt_BR
dc.contributor.authorZanona, Querusche Klippelpt_BR
dc.contributor.authorBecker, Sofia Zaninipt_BR
dc.contributor.authorHerrmann, Ana Paulapt_BR
dc.contributor.authorPiato, Angelo Luis Stapassolipt_BR
dc.date.accessioned2023-11-18T03:27:03Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/267291pt_BR
dc.description.abstractPesticides are widely used in global agriculture to achieve high productivity levels. Among them, fungicides are specifically designed to inhibit fungal growth in crops and seeds. However, their application often results in environmental contamination, as these chemicals can persistently be detected in surface waters. This poses a potential threat to non-target organisms, including humans, that inhabit the affected ecosystems. In toxicologic research, the zebrafish (Danio rerio) is the most commonly used fish species to assess the potential effects of fungicide exposure, and numerous and sometimes conflicting findings have been reported. To address this, we conducted a systematic review and meta-analysis focusing on the neurobehavioral effects of fungicides in zebrafish. Our search encompassed three databases (PubMed, Scopus, and Web of Science), and the screening process followed predefined inclusion/exclusion criteria. We extracted qualitative and quantitative data, as well as assessed reporting quality, from 60 included studies. Meta-analyses were performed for the outcomes of distance traveled in larvae and adults and spontaneous movements in embryos. The results revealed a significant overall effect of fungicide exposure on distance, with a lower distance traveled in the exposed versus control group. No significant effect was observed for spontaneous movements. The overall heterogeneity was high for distance and moderate for spontaneous movements. The poor reporting practices in the field hindered a critical evaluation of the studies. Nevertheless, a sensitivity analysis did not identify any studies skewing the meta-analyses. This review underscores the necessity for better-designed and reported experiments in this field.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 13 (Oct. 2023), 18142, 20 p.pt_BR
dc.rightsOpen Accessen
dc.subjectEcotoxicologiapt_BR
dc.subjectPraguicidaspt_BR
dc.subjectFungicidas industriaispt_BR
dc.subjectPeixe-zebrapt_BR
dc.subjectRevisão sistemáticapt_BR
dc.titleNeurobehavioral effects of fungicides in zebrafish : a systematic review and meta-analysispt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001187749pt_BR
dc.type.originEstrangeiropt_BR


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