Hypoxia-inducible factor-1α (HIF-1α) inhibition impairs retinoic acid-induced differentiation in SH-SY5Y neuroblastoma cells, leading to reduced neurite length and diminished gene expression related to cell differentiation
dc.contributor.author | Brum, Pedro Ozorio | pt_BR |
dc.contributor.author | Viola, Guilherme Danielski | pt_BR |
dc.contributor.author | Girardi, Carolina Saibro | pt_BR |
dc.contributor.author | Ribeiro, Camila Tiefensee | pt_BR |
dc.contributor.author | Brum, Matheus Ozorio | pt_BR |
dc.contributor.author | Gasparotto, Juciano | pt_BR |
dc.contributor.author | Krolow, Rachel | pt_BR |
dc.contributor.author | Moreira, Jose Claudio Fonseca | pt_BR |
dc.contributor.author | Gelain, Daniel Pens | pt_BR |
dc.date.accessioned | 2022-05-07T04:51:04Z | pt_BR |
dc.date.issued | 2022 | pt_BR |
dc.identifier.issn | 0364-3190 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/238322 | pt_BR |
dc.description.abstract | Neuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia—a common feature of the tumoural environment—is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aims to investigate the effects of the selective inhibition of HIF-1α on the differentiation induced by retinoic acid in human neuroblastoma cells from the SH-SY5Y lineage to clarify its role in cell differentiation. Our results indicate that HIF-1α inhibition impairs RA-induced differentiation by reducing neuron-like phenotype and diminished immunolabeling and expression of differentiation markers. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Neurochemical research. New York. Vol. 47, no. 2 (Feb. 2022), p. 409-421 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Neuroblastoma | pt_BR |
dc.subject | Hypoxia | en |
dc.subject | Subunidade alfa do Fator 1 Induzível por Hipóxia | pt_BR |
dc.subject | Differentiation | en |
dc.subject | Neuroblastoma | en |
dc.subject | Tretinoína | pt_BR |
dc.subject | Cancer | en |
dc.subject | Diferenciação celular | pt_BR |
dc.subject | HIF-1 | en |
dc.subject | Células tumorais cultivadas | pt_BR |
dc.subject | SH-SY5Y | en |
dc.title | Hypoxia-inducible factor-1α (HIF-1α) inhibition impairs retinoic acid-induced differentiation in SH-SY5Y neuroblastoma cells, leading to reduced neurite length and diminished gene expression related to cell differentiation | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001139658 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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