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dc.contributor.authorConstantino, Larissa de Souzapt_BR
dc.contributor.authorGalant, Leticia Selingerpt_BR
dc.contributor.authorVuolo, Franciele Silvapt_BR
dc.contributor.authorGuarido, Karla Lorenapt_BR
dc.contributor.authorKist, Luiza Wilgespt_BR
dc.contributor.authorOliveira, Giovanna Medeiros Tavares dept_BR
dc.contributor.authorPasquali, Matheus Augusto de Bittencourtpt_BR
dc.contributor.authorSouza, Cláudio Teodoro dept_BR
dc.contributor.authorSantos, José Eduardo da Silvapt_BR
dc.contributor.authorBogo, Mauricio Reispt_BR
dc.contributor.authorMoreira, Jose Claudio Fonsecapt_BR
dc.contributor.authorRitter, Cristianept_BR
dc.contributor.authorDal Pizzol, Felipept_BR
dc.date.accessioned2019-08-29T02:34:59Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn2197-425Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/198565pt_BR
dc.description.abstractBackground: Extracellular superoxide dismutase (ECSOD) protects nitric oxide (NO) bioavailability by decreasing superoxide levels and preventing peroxynitrite generation, which is important in maintaining renal blood flow and in preventing acute kidney injury. However, the profile of ECSOD expression after sepsis is not fully understood. Therefore, we intended to evaluate the content and gene expression of superoxide dismutase (SOD) isoforms in the renal artery and their relation to renal blood flow. Methods: Sepsis was induced in Wistar rats by caecal ligation and perforation. Several times after sepsis induction, renal blood flow (12, 24 and 48 h); the renal arterial content of SOD isoforms, nitrotyrosine, endothelial and inducible nitric oxide synthase (e-NOS and i-NOS), and phosphorylated vasodilator-stimulated phosphoprotein (pVASP); and SOD activity (3, 6 and 12 h) were measured. The influence of a SOD inhibitor was also evaluated. Results: An increase in ECSOD content was associated with decreased 3-nitrotyrosine levels. These events were associated with an increase in pVASP content and maintenance of renal blood flow. Moreover, previous treatment with a SOD inhibitor increased nitrotyrosine content and reduced renal blood flow. Conclusions: ECSOD appears to have a major role in decreasing peroxynitrite formation in the renal artery during the early stages of sepsis development, and its application can be important in renal blood flow control and maintenance during septic insult.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofIntensive care medicine experimental. Heidelberg. Vol. 5 (Dec. 2017), 15, 12 p.pt_BR
dc.rightsOpen Accessen
dc.subjectSepsept_BR
dc.subjectSepsisen
dc.subjectÁcido peroxinitrosopt_BR
dc.subjectAcute renal failureen
dc.subjectSuperoxideen
dc.subjectSuperóxido dismutasept_BR
dc.subjectNitric oxideen
dc.titleExtracellular superoxide dismutase is necessary to maintain renal blood flow during sepsis developmentpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001098873pt_BR
dc.type.originEstrangeiropt_BR


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