Effects of diabetes and hypertension on oral mucosa and TGFβ1 salivary levels
dc.contributor.author | Bernardi, Lisiane | pt_BR |
dc.contributor.author | Souza, Bárbara Capitanio de | pt_BR |
dc.contributor.author | Sonda, Nicole Canalli | pt_BR |
dc.contributor.author | Visioli, Fernanda | pt_BR |
dc.contributor.author | Rados, Pantelis Varvaki | pt_BR |
dc.contributor.author | Lamers, Marcelo Lazzaron | pt_BR |
dc.date.accessioned | 2019-02-15T02:34:11Z | pt_BR |
dc.date.issued | 2018 | pt_BR |
dc.identifier.issn | 0103-6440 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/188835 | pt_BR |
dc.description.abstract | The aim of this study was to investigate salivary levels of TGFβ1 and proliferation/ maturation of epithelial mucosa cells in diabetic and hypertensive patients. Design: in this cross-sectional study, whole stimulated saliva and oral mucosa exfoliative cytology specimens were collected from 39 patients that were healthy (control, n=10) or presented history of arterial hypertension (HAS, n=9), diabetes mellitus (DM, n=10) or both (DM+HAS, n=10). Salivary flow rate (SFR), TGFβ1 level in saliva, AgNORs and the epithelial maturation were evaluated. Non-parametric Kruskal-Wallis test, followed by Dunn’s multiple comparison post-test and the Spearman test correlation analysis were used. SFR showed a significant decreased in DM and DM+HAS (0.47±0.11 and 0.64±0.43 mL/min) when compared to control (1.4±0.38 mL/min). DM+HAS presented the highest value of TGFβ1 concentration (24.72±5.89 pg/mL). It was observed a positive correlation between TGFβ1 and glycaemia (R=0.6371; p<0.001) and a negative correlation between TGFβ1 and saliva (R=-0.6162; p<0.001) and glycaemia and SFR (R=-0.5654; P=0.001). AgNORs number and status of maturation of mucosa cells were similar for all conditions. DM and DM+HAS presented the lowest SFR, which correlated with increased TGFβ1 levels. Despite the higher TGFβ1 secretion it was not observed changes in the morphology or proliferation of epithelial cells when diabetes or hypertension was present. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian dental journal. Ribeirão Preto. Vol. 29, no. 3 (May/June 2018), p. 309-315 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Salivary flow | en |
dc.subject | Saliva | pt_BR |
dc.subject | AgNORs | en |
dc.subject | Mucosa bucal | pt_BR |
dc.subject | Exfoliative cytology | en |
dc.subject | Fator de crescimento transformador beta1 | pt_BR |
dc.subject | Diabetes mellitus | pt_BR |
dc.subject | Hyperglycemia | en |
dc.subject | Hipertensão | pt_BR |
dc.subject | Blood pressure | en |
dc.title | Effects of diabetes and hypertension on oral mucosa and TGFβ1 salivary levels | pt_BR |
dc.title.alternative | Effects of diabetes and hypertension on oral mucosa and TGF-beta1 salivary levels | en |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001087707 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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