Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess : a randomized clinical trial
dc.contributor.author | Santini, Manuela Favarin | pt_BR |
dc.contributor.author | Rosa, Ricardo Abreu da | pt_BR |
dc.contributor.author | Ferreira, Maria Beatriz Cardoso | pt_BR |
dc.contributor.author | Fischer, Maria Isabel | pt_BR |
dc.contributor.author | Souza, E. M. | pt_BR |
dc.contributor.author | Só, Marcus Vinicius Reis | pt_BR |
dc.date.accessioned | 2018-07-28T02:46:12Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 1678-7757 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/180730 | pt_BR |
dc.description.abstract | Acute periradicular abscess is a condition characterized by the formation and propagation of pus in the periapical tissues and generally associated with debilitating pain. Objective: The aim of this study was to compare the overall analgesic effectiveness of two combinations of opioid and non-opioid analgesics for acute periradicular abscess. Material and Methods: This study included 26 patients who sought emergency care in a Brazilian dental school. The patients were randomly divided into two groups: Co/Ac - oral prescription of codeine (30 mg) plus acetaminophen (500 mg), every 4h, for 3 days or Tr/Ac - oral prescription of tramadol hydrochloride (37.5 mg) plus acetaminophen (500 mg) on the same schedule. Two factors were evaluated: (1) pain scores recorded by the patients in a pain diary 6, 12, 24, 48, and 72 h after treatment, using the Visual Analogue Scale; and (2) the occurrence of adverse effects. Results: In both groups, there was a reduction in pain scores over time. For the Co/Ac group, there was a significant reduction in the scores 12, 24,48, and 72 hours after treatment (P<0.05). In the Tr/Ac group, the scores significantly drecreased over time from time point 6 h (P<0.05). Comparing the pain at each time point, the groups were not significantly different (P>0.05), i.e.,both treatments were effective in controlling pain caused by APA; however, the combination of Tr/Ac caused more adverse reactions as two patients had to stop using the medication. Conclusion: This study suggests that, considering both analgesic efficacy and safety, the combination of codeine and acetaminophen is more effective to control moderate to severe pain from acute periradicular abscesses. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Journal of applied oral science. Bauru. Vol. 25, n. 5 (Sept./Oct. 2017), p. 551-558 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Abscesso periapical | pt_BR |
dc.subject | Analgesia | en |
dc.subject | Codeine | en |
dc.subject | Analgesia | pt_BR |
dc.subject | Periapical abscess | en |
dc.subject | Acetaminofen | pt_BR |
dc.subject | Codeína | pt_BR |
dc.subject | Tramadol | en |
dc.subject | Tramadol | pt_BR |
dc.subject | Visual analog scale | en |
dc.subject | Periodontite | pt_BR |
dc.title | Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess : a randomized clinical trial | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001059493 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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