Hippeastrum reticulatum (Amaryllidaceae) : alkaloid profiling, biological activities and molecular docking
dc.contributor.author | Tallini, Luciana Ruschel | pt_BR |
dc.contributor.author | Osorio López, Edison Humberto | pt_BR |
dc.contributor.author | Santos, Vanessa Dias dos | pt_BR |
dc.contributor.author | Borges, Warley de Souza | pt_BR |
dc.contributor.author | Kaiser, Marcel | pt_BR |
dc.contributor.author | Viladomat, Francesc | pt_BR |
dc.contributor.author | Zuanazzi, Jose Angelo Silveira | pt_BR |
dc.contributor.author | Bastida, Jaume | pt_BR |
dc.date.accessioned | 2018-05-18T02:27:20Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 1420-3049 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/178504 | pt_BR |
dc.description.abstract | The Amaryllidaceae family has proven to be a rich source of active compounds, which are characterized by unique skeleton arrangements and a broad spectrum of biological activities. The aim of this work was to perform the first detailed study of the alkaloid constituents of Hippeastrum reticulatum (Amaryllidaceae) and to determine the anti-parasitological and cholinesterase (AChE and BuChE) inhibitory activities of the epimers (6 -hydroxymaritidine and 6 -hydroxymaritidine). Twelve alkaloids were identified in H. reticulatum: eight known alkaloids by GC-MS and four unknown (6 -hydroxymaritidine, 6 -hydroxymaritidine, reticulinine and isoreticulinine) by NMR. The epimer mixture (6 -hydroxymaritidine and 6 -hydroxymaritidine) showed low activity against all protozoan parasites tested and weak AChE-inhibitory activity. Finally, a molecular docking analysis of AChE and BuChE proteins showed that isoreticulinine may be classified as a potential inhibitory molecule since it can be stabilized in the active site through hydrogen bonds, - stacking and hydrophobic interactions. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Molecules. Basel, Switzerland. Vol. 22, no. 12 (2017), paper 2191 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Amaryllidaceae | pt_BR |
dc.subject | 6 -hydroxymaritidine | en |
dc.subject | 6 -hydroxymaritidine | en |
dc.subject | Reticulinine | en |
dc.subject | Isoreticulinine | en |
dc.subject | Hippeastrum reticulatum | en |
dc.title | Hippeastrum reticulatum (Amaryllidaceae) : alkaloid profiling, biological activities and molecular docking | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001067793 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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